In a dusty cantina on the far side of the Rio Grande, larger-than-life and recently widowed crime writer Hector Lassiter and Bud Fiske, a callow young poet sent by True Magazine to profile Hector, are handed a carpet bag. Inside they find the stolen head of Mexican general Francisco "Pancho" Villa—a long missing relic that may point the way to a fortune in lost treasure or a blood-and-thunder death...

In the dank, hallowed halls of Yale University creep the members of the Skull & Bones, a secret society shrouded in whispers. They are a fraternity whose members include media barons, über executives and politicians, including three generations of men called Bush—and their sanctum sanctorum's trophy cabinet is purportedly packed with the stolen bones of long-dead luminaries...

In a '57 Bel Air, Hector, Bud, and the beautiful Alicia tear through the desert with a trunk full of human heads. Caught in a crazy crossfire, they lead all manner of headhunters on a breakneck chase across Lost America. U.S. intelligence services, murderous frat boys, the soldier of fortune who stole Pancho's head from its grave, and the specter of a dead Mexican legend all want Villa's head—though they might settle for Hector's...